Dexedrine Withdrawal Medication and Treatment Programs
Medically reviewed badge

Dexedrine Withdrawal Medication and Treatment Programs

Dexedrine, also known by its generic name dextroamphetamine, is a prescription stimulant medication intended to treat ADHD.



Dexedrine, also known by its generic name dextroamphetamine, is a prescription stimulant medication intended to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy.1 Some users may abuse the drug to enhance its pleasurable effects or to stay awake and study or work.

Dexedrine abusers may develop a dependence on the drug, which occurs when the body goes through physiological changes after taking the drug for a period of time.2 Dependence can cause users to experience withdrawal symptoms when they try to quit or cut down.2 Symptoms may include depression, low energy, and sleeping problems.2

Detoxing cold turkey can lead to depression, suicidal thoughts, and relapse. Detox centers and other withdrawal treatment programs help Dexedrine users safely go through withdrawal. These programs may prescribe medications to help treat anxiety, depression, and sleep problems. Medical providers may also slowly taper users off Dexedrine to reduce the intensity of symptoms.

Treatment Options for Dexedrine Withdrawal

Withdrawal treatment centers provide inpatient or outpatient care that is aimed at eliminating cravings for alcohol and drugs so that rehabilitation treatment can begin.

  • Detoxification centers allow users to withdraw from Dexedrine while staying in a drug-free facility. Detox programs are staffed with medical and mental health professionals who are able to monitor a person’s withdrawal symptoms 24 hours a day. When detox is complete, the person can transition to inpatient or outpatient substance abuse treatment for additional support.
  • Inpatient detox and recovery programs provide both withdrawal treatment and temporary housing. Like detoxification centers, inpatient programs are able to closely monitor withdrawal symptoms throughout the day. However, inpatient programs also provide addiction treatment in the form of group, individual, and family therapy after the user has detoxed. Luxury and executive inpatient programs offer high-end features such as swimming, horseback riding, and private rooms as well as Internet-connected workspaces.
  • Outpatient detox and recovery programs also provide help for people going through withdrawal. Outpatient treatment offers therapy and medications to treat withdrawal symptoms, but these services are provided on a less frequent basis than other forms of treatment. Outpatient programs do not offer housing or 24-hour care.

Withdrawal Medications

There are currently no medications with FDA approval to specifically treat Dexedrine withdrawal. However, doctors may treat Dexedrine withdrawal with the same medications used to treat withdrawal from cocaine.4 These medications may help relieve some of the symptoms of withdrawal and reduce the risk of relapse. Medications that may be used to treat Dexedrine withdrawal include:

  • Sleep medications such as the antihistamines Benadryl and hydroxyzine (brand name Vistaril), and the antidepressant trazodone (brand name Desyrel) may be used to treat insomnia during withdrawal.3
  • Mirtazapine (brand name Remeron), an antidepressant, has been shown to reduce anxiety during withdrawal.3,5
  • Modafinil (brand name Provigil), a medication that promotes wakefulness, is under review as a possible treatment for cocaine dependence and has been shown to improve abstinence in cocaine-dependent subjects.3,6

Medications are one important aspect of Dexedrine withdrawal treatment. In addition to medications, effective treatment involves support, education, and lifestyle changes.3

Tapering Off Dexedrine

Attempting to taper without professional help or treatment can result in more severe withdrawal symptoms. Doctors may gradually taper users off of Dexedrine, rather than stopping the drug all at once.2 Tapering involves slowly decreasing the dose to ease the withdrawal process and reduce the likelihood of severe depression and fatigue.1 Medical professionals may develop a taper schedule depending on how much of the drug was being used, as well as a person’s body weight, height, and overall health.

Medical professionals consider many factors when developing a taper. Attempting to taper without professional help or treatment can result in more severe withdrawal symptoms, physical discomfort, and possible relapse. The safest way to taper off of Dexedrine is to consult with a healthcare provider.

Detoxing Cold Turkey at Home

Dexedrine withdrawal is generally not life-threatening. But it increases the risk of psychological problems. People withdrawing from Dexedrine may experience depression and suicidal thoughts.3 Treatment programs are able to monitor these symptoms and provide medications and therapy as needed.

Detoxing without the support of a structured treatment program may also increase the risk of a relapse. Many users in withdrawal have cravings, or strong urges to use the drug. The treatment provides a drug-free environment and helps teach tools to cope with cravings. Without the support of treatment, users may be at higher risk of acting on their cravings.

[1]. MedlinePlus. (2016). Dextroamphetamine.

[2]. National Institute on Drug Abuse. (2016). Misuse of prescription drugs.

[3]. Substance Abuse and Mental Health Services Administration. (2015). Detoxification and substance abuse treatment. Treatment Improvement Protocol (TIP) Series, No. 45. HHS Publication No. (SMA) 15-4131. Rockville, MD: Center for Substance Abuse Treatment.

[4]. Srisurapanont, M., Jarusuraisin, N., & Kittirattanapaiboon, P. (2001). Treatment for amphetamine withdrawalThe Cochrane Library.

[5]. Kongsakon, R., Papadopoulos, K. I., &Saguansiritham, R. (2005). Mirtazapine in amphetamine detoxification: A placebo-controlled pilot studyInternational Clinical Psychopharmacology20(5), 253-256.

[6]. Ballon, J. S., & Feifel, D. (2006). A systematic review of modafinil: Potential clinical uses and mechanisms of action. Journal of Clinical Psychiatry67(4), 554-566.