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Dexedrine Withdrawal Signs, Symptoms, and Timeline

Man holding head experiencing dexedrine withdrawal

Dexedrine is the brand name of a prescription medication that contains dextroamphetamine. It is used to treat narcolepsy and attention-deficit hyperactivity disorder by boosting attention, alertness, and energy.1,2,3

If someone uses Dexedrine for an extended period of time or abuses the medication, they can develop tolerance, dependence, and addiction.1,3 Withdrawal symptoms can arise when a person who is dependent or addicted stops taking it.

Signs can include fatigue, increased appetite, irritability, and depression. The timeline for these effects can last up to 2 weeks. Medical risks of withdrawal include heart problems, depression, and psychotic symptoms.

Due to medical and mental health risks, a person who wants to quit Dexedrine should seek professional detoxification.

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If you’re ready to explore Dexedrine withdrawal treatment options, talk to a helpline representative today at 1-888-935-1318Who Answers?.

Signs, Symptoms, and Effects

Dextroamphetamine Withdrawal

girl sitting against wall in dextroamphetamine withdrawal

The most common dextroamphetamine withdrawal symptoms are extreme fatigue, depression, and anxiety.

Read More

Withdrawal signs and symptoms begin to emerge as the body adjusts to functioning without Dexedrine.

Withdrawal signs for Dexedrine and other amphetamines include a range of physical and mental health symptoms, such as:4,5,6

  • Dehydration.
  • Low energy and fatigue.
  • Strong hunger.
  • Chills.
  • Jittery reactions.
  • Inability to sleep, then long periods of sleep.
  • Agitation.
  • Irritability.
  • Anxiety.
  • Poor memory.
  • Low interest in pleasurable activities.
  • Little desire for social interactions.
  • Dreams about Dexedrine and substance use.
  • Low mood with possible depression.

The onset, intensity, and duration of these effects varies according to:

  • The amount of Dexedrine used.
  • The frequency of use.
  • The duration of use.
  • The route of administration (taken orally, snorted, etc.)
  • Whether the medication was combined with other substances.
  • History of complicated withdrawal or mental health conditions.

Generally, someone who has used low doses of Dexedrine infrequently for a short time will experience less intense withdrawal symptoms that do not last very long. Someone who frequently abused the substance at high doses for long periods will likely have a more uncomfortable or dangerous withdrawal process.

Post-Acute Withdrawal Symptoms

woman in bed having trouble sleepingAs part of what’s known as post-acute withdrawal syndrome (PAWS), some withdrawal symptoms may persist longer than the normal timeframe of Dexedrine withdrawal. These lingering effects can include problems with executive control in the brain, which impacts:7

  • Memory.
  • Decision making.
  • Problem-solving abilities.

Other signs and symptoms include:

  • Anxiety.
  • Mood swings.
  • Trouble sleeping.
  • Strong cravings. 6

These symptoms can last 1-2 months or longer. 6

Dexedrine withdrawal symptoms can be quite serious and require professional treatment to ensure the person’s safety and well-being. If you are considering addiction treatment for yourself or a loved one, call 1-888-935-1318Who Answers? to find options.

Withdrawal Timeline

Typical Dexedrine Withdrawal Timeline
Time Since QuittingSymptoms
The crash (few hours to a day after quitting)People who abuse stimulants such as Dexedrine tend to use them in binges.4,5 When the binge ends, the user goes through a “crash” as the drug’s effects wear off. Symptoms can appear within a few hours or up to one day following the last use of Dexedrine.6 During this time, the user will often be unable to sleep and appear jittery.4
24 hours to 5 days after last useAs withdrawal continues, the person will become very tired, hungry, and thirsty. In this stage, the person will require large meal portions, plenty of fluids, and a calm environment to rest.5
5 days to 2 weeks after last useDexedrine withdrawal signs usually last from 3 to 5 days. But they can last as long as 2 weeks.6,7 The symptoms of protracted withdrawal, when present, can last 1-2 months or longer.7

Medical Complications

The medical risk of Dexedrine withdrawal is low. But as a result of prolonged stimulant abuse, some individuals in withdrawal may experience:5

  • Cardiac problems, which may develop in some users due to the cardiotoxic effects of Dexedrine on the heart and cardiovascular system. Potential issues include ischemia (poor blood flow to the heart), infarction (heart attack), or stroke.
  • Seizures, which are rare, but have been known to occur during stimulant withdrawal.

Some people may become so depressed that they harm themselves or attempt suicide.

The largest medical risks of Dexedrine withdrawal are severe depression, agitation, and psychotic symptoms. These effects can be more intense and prevalent in people with a previous mental health history.4,5,6

Some people may become so depressed that they harm themselves or attempt suicide. Other people may become disconnected from reality during detoxification and experience hallucinations, delusions, and paranoia. These symptoms may trigger violence and aggression toward others.

Other problems such as poor sleep, headaches, and anxiety may be treated with prescription or over-the-counter medications.

Due to the potential for dangerous mental and physical health complications, Dexedrine withdrawal should always be taken seriously and treated by a professional.

Find a Detox Center

If you or someone you care about is ready to detox from Dexedrine, call 1-888-935-1318Who Answers? today. Find a detox center to ensure safety and improve your chances of long-term recovery.

Read next: Dexedrine Withdrawal Medications and Help


[1]. U.S. Food and Drug Administration. (2015). Dexedrine.

[2]. U.S. National Library of Medicine: MedlinePlus. (2016). Dextroamphetamine.

[3]. National Institute on Drug Abuse for Teens. (2016). Prescription Stimulant Medications (Amphetamines).

[4]. Substance Abuse and Mental Health Services Administration. (2001). Treatment for Stimulant Use Disorders: Quick Guide for Clinicians.

[5]. Substance Abuse and Mental Health Services Administration. (2015). Detoxification and Substance Abuse Treatment.

[6]. World Health Organization. (2009). Clinical Guidelines for Withdrawal Management and Treatment of Drug Dependence in Closed Setting.

[7]. Substance Abuse and Mental Health Services Administration. (2010). Protracted Withdrawal.

[8]. National Institute of Health. (2010). The Brain: Understanding Neurobiology.

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