GHB Withdrawal Medication Options - Withdrawal
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GHB Withdrawal Medication Options

Repeated use of GHB can lead to dependence and physical and emotional withdrawal symptoms when a person attempts to stop. Here's what you need to know.

Gamma-hydroxybutyrate (GHB)—sometimes known as liquid ecstasy—is an FDA-approved drug for the treatment of narcolepsy.1 In recent years, GHB has gained a reputation as a “club drug,” and users have taken it illegally to enhance their experiences at bars and nightclubs.

Repeated use of GHB over time can lead to dependence and physical and emotional withdrawal symptoms when a person attempts to stop or cut down.2,3 Some GHB users may also abuse other drugs, such as alcohol, which can cause an additional complicated withdrawal.1,3,6

Withdrawal from GHB can be dangerous and should be monitored by a medical professional. Some users may resist seeking help until they are already experiencing severe withdrawal symptoms. Unfortunately, more severe withdrawal reactions may be harder to treat and can lead to long-term physical and emotional health problems and, in rare cases, even death.3

Seeking help early on can prevent severe symptoms and ensure a safer withdrawal process. A variety of treatment options can provide medical care as well as medications to manage symptoms.

Withdrawal Management

Medications used to treat GHB withdrawal include:2,3,4,5

  • Benzodiazepines, such as diazepam and lorazepam. These longer-acting benzodiazepines can help reduce symptoms of anxiety and delirium. Higher doses may be prescribed in cases of severe withdrawal.
  • Barbiturates, which have similar effects to benzodiazepines. Though increasingly rarely used, they can sedate and reduce agitation and anxiety that might not respond well to other pharmaceutical interventions.
  • Gabapentin, a mood stabilizer.
  • Baclofen, a GABAB agonist that works on the same receptor as GHB.
  • Antipsychotic drugs, such as phenothiazines. This class of drugs can treat psychotic symptoms during withdrawal, such as hallucinations.
  • Anticonvulsant drugs, which can reduce the risk of seizures.

The specific dose of a medication for GHB withdrawal may depend on several factors, including the severity of withdrawal symptoms and a person’s physical and emotional health. Users who are treated with certain medications, such as benzodiazepines and barbiturates, may be slowly tapered off of them after their withdrawal symptoms are controlled.2

Users may also be in withdrawal from other drugs, such as alcohol, marijuana, stimulants, and opioids. Treatment programs can help the user detox from multiple drugs by treating symptoms for each specific drug. This can reduce the likelihood of adverse reactions.

Withdrawal treatment programs may also monitor the user’s vital signs and check for other dangerous conditions, such as hyperthermia and rhabdomyolysis (a condition of muscle tissue breakdown).3 Participants can rest in a calm environment with little stimulation.

Therapy & Treatment for GHB Addiction

Users who are addicted to or dependent on GHB may need more than medications to effectively quit the drug. Cognitive-behavioral therapy, or CBT, helps people understand the relationship between their thoughts, feelings, and behaviors and develop coping skills to manage cravings. Medications combined with behavioral therapies can help prevent relapse and increase the likelihood of a full recovery. Treatment programs can provide both medical treatment for withdrawal and psychological interventions such as group, individual, and family therapy.

Detox Centers and Rehab Programs for GHB Addiction

Detox facilities can provide medical and psychological therapies to help ease withdrawal symptoms and prevent dangerous and life-threatening symptoms. GHB withdrawal treatment may take place in one or more of the following settings:

  • Detox centers provide 24-hour support and monitoring for the duration of withdrawal. Some hospitals also have their own detox programs staffed with doctors and nurses who provide necessary treatments, including medications. Once detox is complete, a person may be referred to a rehab program for continued treatment.
  • Inpatient treatment programs provide both detox and addiction treatment. Staff members monitor vital signs and symptoms and provide medications to reduce the risk of adverse reactions. Participants are encouraged to rest during the early stages of withdrawal. Once withdrawal is complete, participants can take part in group, individual, and family therapy sessions and other therapeutic activities.
  • Outpatient treatment programs provide detox and addiction treatment for people that have a safe place to stay, a good support system in place, and are at low risk of experiencing a complicated or life-threatening withdrawal. Participants may go to the treatment facility several days a week, where staff members can monitor their withdrawal and provide any treatments that may be necessary. Medical professionals may also prescribe medications for participants to take home if they feel that they are medically stable.

The right type of withdrawal treatment depends on each person’s needs. Choosing the best type of treatment may depend on several factors:

  • How long a person has been using GHB
  • How much GHB a person has been using
  • Whether the person used GHB with other drugs or alcohol
  • Whether a person is experiencing other physical or mental health conditions
  • Severity of withdrawal symptoms in the past
  • How much family and peer support a person has in place
  • Whether a person has stable housing or transportation to get to treatment

Some GHB users may choose not to seek help for withdrawal because of the cost of treatment. Fortunately, low-cost inpatient and outpatient treatment programs are available. Users and their families can also cover the cost of treatment with savings, credit cards, loans, health insurance, and payment plans. The cost should not prevent you from seeking help.

Going Cold Turkey at Home

Detoxing from GHB cold turkey can be dangerous. GHB withdrawal can lead to psychotic symptoms, such as hallucinations, as well as rapid heart rate, high blood pressure, and rarely, seizures.2 Symptoms may appear mild at first and then quickly escalate. If not properly treated, these symptoms can have long-term consequences and may even lead to death.3

Going through GHB withdrawal in a licensed treatment program is the safest method of detoxing. Treatment programs are staffed with medical and mental health professionals that can monitor and treat mild to severe withdrawal symptoms. If you or someone you know needs help for GHB withdrawal, consider a detox center.

1. National Institute on Drug Abuse. (2014). DrugFacts: Club drugs: GHB, Ketamine, and Rohypnol.
2. Ries, R. K., Fiellin, D. A., Miller, S. C., & Saitz, R. (2014). The ASAM principles of addiction medicine (5th ed.). Philadelphia, PA: Lippincott Williams & Wilkins.
3. McDonough, M., Kennedy, N., Glasper, A., & Bearn, J. (2004). Clinical features and management of gamma-hydroxybutyrate (GHB) withdrawal: A review. Drug and Alcohol Dependence, 75(1), 3-9.
4. LeTourneau, J. L., Hagg, D. S., & Smith, S. M. (2008). Baclofen and gamma-hydroxybutyrate withdrawal. Neurocritical Care, 8(3), 430-433.
5. Tarabar, A. F., & Nelson, L. S. (2004). The γ-hydroxybutyrate withdrawal syndrome. Toxicological Reviews, 23(1), 45-49.
6. Miotto, K. & R. B. (2001). GHB withdrawal syndrome. Austin: Texas Commission on Alcohol and Drug Abuse.